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modafinil will lower the extent or effect of pacritinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.No particular dose adjustment advised when tofacitinib coadministered with potent CYP2C19 inhibitors; minimize tofacitinib dose if coadministered with both average CYP3A4 and powerful CYP2C19 inhibitors .Modafinil is usu
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